Posted February 8, 2019
Twenty years ago, Johnson & Johnson’s AN1792 Alzheimer’s vaccine showed early promise in terms of safety and tolerability, but was pulled from phase 2 testing when six percent of patient volunteers developed an immune-mediated brain inflammation (meningoencephalitis), and one person died. Since then, several other vaccines have gone into development, all attempting to reduce accumulation of the damaged target proteins without provoking the dangerous brain inflammation. Read more.